Divergent Injury Pathways in Neonatal Intestine and Kidney: Quantitative Morphology of Necrotizing Enterocolitis and Multicystic Dysplastic Kidney
Keywords:
necrotizing enterocolitis, multicystic dysplastic kidney, histologic grading, neonatal pathology, intestinal injury, renal dysplasia, morphologyAbstract
Necrotizing enterocolitis (NEC) and multicystic dysplastic kidney (MCDK) are leading neonatal entities that exemplify acute inflammatory necrosis versus chronic developmental disorganization on histology. Contemporary grading systems for NEC now quantify depth and extent of intestinal injury, ranging from mucosa‑limited changes to transmural necrosis, and can be complemented by weighted, cumulative point scores capturing subtle mucosal lesions., In parallel, recent series of MCDK describe a histomorphological spectrum defined by primitive ducts with mesenchymal collars, cyst burden, and heterologous elements, with semi‑quantitative assessments of residual parenchyma and later autoinvolution. This article integrates classic pattern‑based descriptions with simplified ordinal scoring to compare tissue injury in NEC and MCDK, illustrated by a bar graph that contrasts histologic severity categories across both diseases. The resulting framework underscores how quantitative morphology can refine diagnosis, prognostication, and study design in neonatal intestinal and renal pathology.
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