Non-Alcoholic Fatty Liver Disease in Comorbid Patients: Experience with Tiotriazoline Therapy
Keywords:
non-alcoholic fatty liver disease, comorbidity, Tiotriazoline, hepatoprotection, oxidative stress, metabolic syndrome, type 2 diabetes mellitus, cardiovascular riskAbstract
Background: Non-alcoholic fatty liver disease (NAFLD) is a common condition associated with obesity, type 2 diabetes, dyslipidemia, hypertension, and cardiovascular disease. In comorbid patients, its progression is driven by insulin resistance, oxidative stress, and chronic inflammation. Tiotriazoline is a hepatoprotective antioxidant with potential therapeutic effects on liver injury. Objective: To evaluate the clinical and laboratory effectiveness of Tiotriazoline in comorbid patients with NAFLD. Methods: Patients with NAFLD and comorbid type 2 diabetes, obesity, and ischemic heart disease were assessed before and after therapy including Tiotriazoline. Evaluations included clinical symptoms, liver enzymes, lipid profile, glucose levels, and ultrasound signs of steatosis. Results: Treatment with Tiotriazoline was associated with improved well-being and reduced asthenic and dyspeptic symptoms. Laboratory findings showed decreased aminotransferase levels and improved metabolic parameters. The effect was more pronounced in moderate steatosis without advanced fibrosis. The therapy was well tolerated and did not worsen cardiovascular conditions. Conclusion: Tiotriazoline may be an effective component of complex therapy in NAFLD patients with comorbidities. Its antioxidant and metabolic effects contribute to improved liver function and clinical outcomes.
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