Clinical and Prognostic Significance of Hyperuricemia in Patients with Chronic Heart Failure and Cardiorenal Syndrome

Authors

  • Moxidil Maxmudova Fergana Medical Institute of Public Health

Keywords:

chronic heart failure, hyperuricemia, serum uric acid, cardiorenal syndrome, estimated glomerular filtration rate, albuminuria, prognosis

Abstract

Background: Chronic heart failure is often accompanied by renal dysfunction and cardiorenal syndrome. Hyperuricemia is increasingly recognized not only as a metabolic disorder but also as a marker of oxidative stress, inflammation, endothelial dysfunction, impaired renal perfusion, and poor prognosis. Its interaction with heart and kidney dysfunction may contribute to disease progression and increased cardiovascular risk. Objective: To evaluate the clinical and prognostic significance of hyperuricemia in patients with chronic heart failure and cardiorenal syndrome. Methods: This observational study included 142 patients with NYHA class II–IV heart failure and renal dysfunction. Clinical parameters, serum uric acid, renal function markers, inflammatory indicators, ECG, and echocardiography were assessed. Patients were divided into hyperuricemia and normouricemia groups (defined as >420 μmol/L in men and >360 μmol/L in women). Clinical severity, renal function, cardiac parameters, and hospitalization rates were compared. Results: Hyperuricemia was present in 45.1% of patients. These patients showed more advanced heart failure, lower ejection fraction, worse renal function, higher inflammatory markers, and more frequent congestion. Rehospitalization rates were higher in the hyperuricemia group. The combination of hyperuricemia, reduced eGFR, and albuminuria identified a subgroup at particularly high risk. Conclusion: Hyperuricemia has important clinical and prognostic value in chronic heart failure with cardiorenal syndrome. It may serve as a useful biomarker for risk stratification, especially when combined with renal and inflammatory markers, supporting improved monitoring and management.

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Aripov, A. (2026). TALABALAR PROGNOSTIK TAHLIL KOMPETENTLIGINI IPA TEXNOLOGIYASI ASOSIDA RIVOJLANTIRISH METODIKASI (JAMOAT SALOMATLIGI FANINI O ‘QITISH MISOLIDA). Лучшие интеллектуальные исследования, 67(2), 464-470.

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2026-05-06

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Maxmudova , M. (2026). Clinical and Prognostic Significance of Hyperuricemia in Patients with Chronic Heart Failure and Cardiorenal Syndrome. Journal of Clinical and Biomedical Research, 2(5), 79–87. Retrieved from https://medjournal.it.com/index.php/jcbr/article/view/140

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