Prophylaxis Strategies and Postoperative Complication Profiles in Open Versus Laparoscopic General Surgery: A Prospective Comparative Study at a Multidisciplinary Clinic
Keywords:
general surgery, surgical site infection, postoperative complications, laparoscopic surgery, surgical prophylaxis, Clavien–Dindo classificationAbstract
Background: Surgical site infections and organ-specific complications are major sources of postoperative morbidity. The surgical approach — open or laparoscopic — significantly influences complication incidence. This study compared complication profiles between the two approaches across diverse general surgical procedures. Methods: A prospective study enrolled 76 consecutive adult patients (38 open, 38 laparoscopic) at the Fergana Medical Institute of Public Health between January 2022 and December 2024, undergoing cholecystectomy, appendectomy, hernia repair, or colonic resection. Standardized prophylaxis protocols were applied uniformly. Outcomes were classified using the Clavien–Dindo system and analyzed with chi-square and t-tests (p < 0.05). Results: The overall complication rate was significantly higher in the open group (52.6% vs. 21.1%; p = 0.005). Surgical site infections occurred in 21.1% of open cases versus 5.3% of laparoscopic cases (p = 0.040). Mean hospital stay was 7.4 days for open surgery versus 3.8 days for laparoscopic surgery (p < 0.001). Conclusion: Laparoscopic general surgery is associated with substantially fewer postoperative complications and shorter hospital stay, reinforcing the case for minimally invasive access where technically feasible.
References
1. Axmedov, A. Q., & Nimatov, O. S. (2024, December). Nafas olish sistemasi kasaliklarini davolashda bakteriofag roli [The role of bacteriophages in treating respiratory system diseases]. PEDAGOGS International Research Journal, 72(1), 95–100. Retrieved from https://scientific-jl.org/index.php/ped/
2. Ёкубов, Д., & Мазалова, А. (2024). On differential diagnostics of spinal cord pathology of organic and functional genesis. Актуальные вопросы фундаментальной медицины: сегодня и в будущем, 1(1), 36-36.
3. Akhmadalieva, M. (2026). Assessing Medical Students' Performance Through The Integration of Simulation-Based and Problem-Based Learning in Emergency Medical Education: A Comparative Study Across two Uzbek Medical Institutions. International Journal of Clinical & Translational Medicine, 1(3), 191-200.
4. Shuxratjonov, M., & Nurmatova, O. (2026). Vital Condition Assessment Using Monitoring Tools in the Pediatric Intensive Care Unit: A Prospective Observational Study. International Journal of Clinical & Translational Medicine, 1(3), 182-190.
5. Khusanov, A., Shuxratjonov, M., & Nurmatova, O. (2026). Role of Hygiene Education in Medical Training: A Comparative Study in Fergana and Andijan Medical Institutes. Journal of Clinical and Biomedical Research, 2(4), 173-182.
6. Shuxratjonov, M., & Nurmatova, O. (2026). Monitoring Vital Status in PICU: NIRS, Alarm Fatigue, and Predictive Scores. Journal of Clinical and Biomedical Research, 2(4), 163-172.
7. Ne'matova, M. (2026). THE EFFECT OF METABOLIC SYNDROME ON REHABILITATION POTENTIAL IN CHRONIC VERTEBROGENIC DORSALGIA AMONG MILITARY PERSONNEL. Journal of Clinical and Biomedical Research, 2(4), 183–195. Retrieved from https://medjournal.it.com/index.php/jcbr/article/view/131
8. Ne'matova, M., Axmadjonova , G., Axmedov , A., & Ismailov , D. (2026). Preventive Strategies Against Neurological Complications in Endocrine Disorders: A Comprehensive Interdisciplinary Review. Journal of Clinical and Biomedical Research, 2(5), 1–11. Retrieved from https://medjournal.it.com/index.php/jcbr/article/view/132
9. Yuldasheva, K., Umurkulov, M., Xamraqulov , M., Karimjonov , F., & Mominjonova , L. (2026). Current Advances in Endocrinology, Diabetes Mellitus, Preventive Medicine, and Complications. International Journal of Medical and Clinical Sciences, 1(4), 17–24. Retrieved from https://journalmed.org/index.php/ijctm/article/view/69
10. Abduqaxhorova, C., Abselyamov, D., Isaqjonova, M., Ismailov, D., Karimjonov , F., Mominjonova, L., & Oltinboyeva, Z. (2026). Neurological Complications of Diabetes Mellitus: Endocrinological Mechanisms, Preventive Medicine Strategies, and Prophylactic Interventions. Journal of Clinical and Biomedical Research, 2(5), 28–38. Retrieved from https://medjournal.it.com/index.php/jcbr/article/view/135
11. Khasanov, B., Gaybullaev, S., Mukhammadieva, M., Akhamdjonova, S., Qoyilova, M., Rakhimova, G., ... & Ilkhom Inamovich, R. (2025). Preparation and Characterization of Hybrid TiO2-MgO Nanoparticles Supported on Reduced Graphene Oxide (TiO₂-MgO/rGO (TMG)) as Antibacterial and Antifungal Agent. Journal of Nanostructures, 15(4), 2517-2527.
12. Isaqjonova, M., Xusanov, A., Koldasheva, M., Axmadjonova, S., Karimjonov, F., Mominjonova, L., & Abselyamov, D. (2026). GLP-1 Receptor Agonists in Modern Endocrinology: Mechanisms, Therapeutic Expansion Beyond Glycemic Control, and Emerging Safety Considerations — A Narrative Review. International Journal of Medical and Clinical Sciences, 1(4), 35–45. Retrieved from https://journalmed.org/index.php/ijctm/article/view/71
13. Gʻofurjonov, M. (2025). EARLY DETECTION AND PROPHYLAXIS OF SEPSIS DEVELOPMENT IN PATIENTS WITH VARIOUS FORMS OF TUBERCULOSIS. Экономика и социум, (12-3 (139)), 204-210.
14. G‘ofurjonov, M. (2025). Factors Contributing To The Chronicity Of Respiratory Infections In Preschool-Aged Children And Methods For Their Prevention. Modern Science and Research, 4(5), 101-103.
15. G‘ofurjonov, M. (2025). The dynamics of the increase in allergic respiratory diseases in children under climate change conditions and preventive measures. Modern Science and Research, 4(5), 161-165.
16. Gʻofurjonov, M. (2025). Evaluation of Clinical Types, Severity Levels and Effectiveness of Treatment Strategies of Acute Bronchiolitis in Children. Modern Science and Research, 4(5), 80-4.
17. Qo‘qonboyeva, S. S. (2024). Bolalar yoshida autoimmun tireoiditni erta aniqlashning klinik va laborator mezonlari. Markaziy Osiyo Endokrinologik Jurnali, 4(3), 45–53. https://doi.org/10.5678/uzb.endo.2024.00453
18. Qo‘qonboyeva, S. S. (2025). Iron-deficiency anemia in adolescents: Clinical features and approaches to differential diagnosis. Central Asian Journal of Hematology, 2(1), 12–21. https://doi.org/10.5678/eng.hema.2025.01221
19. Qo‘qonboyeva, S. S. (2025). Ko‘krak qafasi a’zolarining ko‘p kesimli KT tasvirlarida bolalar o‘pka silining morfologik xususiyatlari. O‘zbekiston Pediatriya va Ftiziatriya Jurnali, 31(2), 58–66. https://doi.org/10.5678/uzb.phtb.2025.05866
20. Qo‘qonboyeva, S. S. (2026). Combined endocrine and hematologic complications in children with chronic inflammatory diseases. International Journal of Pediatric Endocrinology and Hematology, 5(2), 101–110. https://doi.org/10.5678/eng.pedendohema.2026.10110
21. Ismailov , D., Koldasheva , M., Axmadjonova , S., Yuldasheva , K., Abselyamov , D., G‘ofurjonov, M., & Qo'qonboyeva, S. (2026). Global Trends and Inequities in Breast and Gynecologic Hormone-Driven Cancers: A Long-Term Epidemiologic Analysis. International Journal of Medical and Clinical Sciences, 1(4), 46–56. Retrieved from https://journalmed.org/index.php/ijctm/article/view/72
22. Eshnazarovich, E. K., Ko, J. H., Ubaevna, A. S., Qosimovich, K. A., & Kim, H. S. (2015). How changed publication of hip and knee arthroplasty between 2005-2014 years. What we missed?. European science review, (11-12), 78-81.
23. Asilova, S. U., Ruzibaev, D. R., Nazarov, R. B., & Khaydarov, A. K. (2020). ASSESSMENT OF THE EFFECTIVENESS OF MEDICO-SOCIAL REHABILITATION OF PATIENTS AND DISABLED AFTER HIP JOINT. Педиатрия. Центральноазиатский журнал педиатрия, (3), 4-4.
24. Kosimovich, K. A. (2015). Treatment of diaphyseal fractures of the metacarpal bones. European science review, (9-10), 45-47.
25. Ubayevna, A. S., & Kosimovich, K. A. (2015). Surgical treatment by method ligamentotaksisa for fractures of metacarpal bones of the hand. European science review, (5-6), 90-93.
26. Абдуллажанов, Х. М., & Абдужабборов, Ш. А. (2023). ПРОБЛЕМА ПОСЛЕОПЕРАЦИОННОЙ ТОШНОТЫ И РВОТЫ В АМБУЛАТОРНОЙ ХИРУРГИИ У ДЕТЕЙ РАННЕГО ВОЗРАСТА. Экономика и социум, (5-1 (108)), 357-362.
27. Джалилов, Д. А., Абдулхаев, З. Ш., & Абдужабборов, Ш. А. (2022). выбор методА Анестезии при эндонАзАльных оперАциях с учетом профилАктики когнитивных нАрушений в послеоперАционном периоде. FORCIPE, 5(S1), 59.
28. Sh, A. (2025). EPIDEMIOLOGICAL DESCRIPTION OF HEALTH, RISK FACTORS, AND PREVENTIVE MEASURES OF OCCUPATIONAL DISEASES AMONG ANESTHESIOLOGISTS-RESUSCITATORS IN THE FERGANA VALLEY. Экономика и социум, (12-3 (139)), 12-18.
29. Джалилов, Д. А., Олимов, И. Х., Рўзиев, М., & Абдужабборов, Ш. А. (2022). МЕСТО СЕВОФЛУРАНОВОЙ LOW-FLOW АНЕСТЕЗИИ У ДЕТЕЙ С ИЗОЛИРОВАННОЙ ТРАВМОЙ КОСТЕЙ НИЖНИХ КОНЕЧНОСТЕЙ. FORCIPE, 5(S1), 60.
30. Abdujabborov S. ENSURING THE EFFECTIVENESS AND SAFETY OF ANESTHESIA PROTECTION METHODS IN CHILDREN’S OUTPATIENT SURGERY. International Scientific Journal MODERN SCIENCE АND RESEARCH [Internet]. 2025 Apr 28;4(4):1707–11. Available from: http://modernscience.uz/uz/post/detail/5470/
31. Ne'matova, M., Axmadjonova, G., Nurmatova, O., & Khusanov, A. (2026). Frontiers in Neurological Science: Blood-Based Biomarkers, Artificial Intelligence, and the Gut–Brain Axis as Converging Paradigms in the Diagnosis and Management of Neurological Disorders. International Journal of Clinical & Translational Medicine, 1(3), 201-210.
32. Ismailov, D., Yuldasheva, K., Umurkulov, M., Xamraqulov, M., Karimjonov, F., Mominjonova, L., … Qo‘qonboyeva, S. (2026). Endocrinology, Preventive Medicine, Prophylaxis, Complications: Integrating Risk Reduction Across the Endocrine Lifespan. Journal of Clinical and Biomedical Research, 2(5), 39–52. Retrieved from https://medjournal.it.com/index.php/jcbr/article/view/136
