Prenatal Viral Exposure and Neonatal Gastrointestinal Morbidity: A Case-History Study from Fergana
Keywords:
newborn, gastrointestinal disorders, pregnancy, viral infection, congenital infection, cholestasis, cytomegalovirus, case historyAbstract
This article examines gastrointestinal morbidity in newborns born to mothers with documented viral infection during pregnancy using a comparative case-history design based on records from the gastroenterology department of the Fergana Regional Children's Multidisciplinary Medical Center. A total of 138 exposed mother–newborn dyads were compared with 138 dyads without documented viral infection. The analysis focused on feeding intolerance, vomiting, abdominal distension, cholestatic manifestations, prolonged jaundice, altered stool pattern, and early postnatal weight gain. Across nearly all outcomes, the exposed cohort showed higher frequencies, especially for prolonged jaundice, feeding intolerance, and cholestasis. The observed pattern supports the concept that prenatal viral exposure may disturb fetoplacental regulation, hepatic adaptation, intestinal colonization, and postnatal digestive resilience. These findings argue for targeted neonatal surveillance among infants with maternal infectious history and for closer integration of obstetric and pediatric risk stratification.
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