Adiponectin as a Non-Invasive Biomarker for Early Hepatic Steatosis Detection in Chronic Hepatitis B and Delta Coinfection
Keywords:
adiponectin, hepatic steatosis, chronic hepatitis B, hepatitis delta virus, HDV coinfection, non-invasive biomarker, metabolic liver diseaseAbstract
Background: Hepatic steatosis complicates the clinical course of chronic hepatitis B (CHB) coinfected with hepatitis delta virus (HDV), yet reliable non-invasive early detection tools remain limited. Objective: To evaluate serum adiponectin as an early diagnostic biomarker of hepatic steatosis in CHB-HDV coinfected patients. Methods: A cross-sectional study enrolled 130 CHB-HDV patients stratified by controlled attenuation parameter (CAP). Serum adiponectin was measured by ELISA and correlated with steatosis grade, metabolic indices, and liver enzymes. Results: Adiponectin levels declined significantly with increasing steatosis severity (S0: 12.4 ± 0.8 μg/mL; S3: 4.3 ± 0.5 μg/mL; p < 0.001). An adiponectin threshold of 6.0 μg/mL yielded sensitivity of 82% and specificity of 79% for hepatic steatosis. Negative correlations were observed with BMI, HOMA-IR, ALT, and viral load. Conclusion: Serum adiponectin is a practical, cost-effective, and minimally invasive biomarker for early identification of hepatic steatosis in CHB-HDV coinfection, supporting its integration into routine hepatological screening.
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