Pathomorphological and Histochemical Changes in Regional Lymph Nodes in Alcoholic Pancreatitis: An Autopsy-Based Analysis
Keywords:
alcoholic pancreatitis, lymph node morphology, histochemistry, autopsy, sinus histiocytosis, lymphoid hyperplasia, pancreatic immunopathologyAbstract
Background: Alcoholic pancreatitis induces systemic immunological responses that are reflected in the lymphatic apparatus of the pancreas. The regional lymph nodes serve as critical immunological sentinels, yet their structural and histochemical alterations remain incompletely characterised. Methods: Autopsy material from regional pancreatic lymph nodes was obtained from 40 deceased individuals: 22 with acute alcoholic pancreatitis (AP), 18 with chronic AP, and 10 controls. Haematoxylin-eosin, Masson's trichrome, PAS, Alcian Blue, Sudan III, and Gomori silver staining were applied. Semi-quantitative scoring and statistical analysis were performed. Results: Both forms of AP demonstrated significant lymphoid hyperplasia, sinus histiocytosis, and paracortical expansion. Acute AP showed pronounced haemorrhagic infiltration and necrotic foci, whereas chronic AP exhibited dominant fibrotic remodelling and glycogen depletion. Histochemical analysis revealed progressive accumulation of acid mucopolysaccharides and neutral lipids alongside reticular fibre fragmentation. Conclusion: Regional lymph nodes in alcoholic pancreatitis undergo distinct morphological and histochemical transformations depending on disease acuity, reflecting dynamic immune dysregulation and stromal remodelling.
References
1. Abduazizov , E., Abduvosiyev , A., Gofurov , A., Yuldashev, H., Madolimov , A., Nazirtashova , R., & Xusanboyev , B. (2026). Optimizing Antibiotic Stewardship in Pediatric Community-Acquired Pneumonia: Clinical Pathways, Outcomes, and Emerging Challenges. Journal of Clinical and Biomedical Research, 2(5), 208–218. Retrieved from https://medjournal.it.com/index.php/jcbr/article/view/153
2. Abduvasiyevna, K. X. (2026). GENETIK KASALLIKLAR VA ULARNING MOLEKULYAR ASOSLARI. Ustozlar uchun, 89(1), 159-165.
3. Abduvosiyev , A., Abdubannop, M., Yuldashev, H., Nazirtashova , R., Gofurov , A., Abduazizov , E., & Xusanboyev , B. (2026). Perioperative Preventive Strategies to Reduce Surgical Site Infections: A Comparative Analysis of Bundled Protocols. International Journal of Medical and Clinical Sciences, 1(4), 158–168. Retrieved from https://journalmed.org/index.php/ijctm/article/view/84
4. Abduvosiyev , A., Jabborov , A., Maxmudova , M., Mirzajonova , Z., Muslimov , G., Ne'matjonov , B., … O'rinov , A. (2026). Community-Acquired Pneumonia in Children Under Five: Etiology, Diagnosis, and Evidence-Based Management Strategies. Journal of Clinical and Biomedical Research, 2(5), 174–184. Retrieved from https://medjournal.it.com/index.php/jcbr/article/view/150
5. Ergasheva, N. A. (2022). Histopathological patterns of autoimmune thyroiditis in young adults: A single‑center retrospective study. Central Asian Journal of Diagnostic Pathology, 4(1), 19–28. https://doi.org/10.5678/cajdp.2022.4.1.0019
6. Ergasheva, N. A. (2023). Morphological features of Helicobacter pylori‑associated gastritis and their correlation with endoscopic findings. Eurasian Journal of Gastrointestinal Pathology, 2(3), 55–64. https://doi.org/10.5678/ejgp.2023.2.3.0055
7. Ergasheva, N. A. (2024). Immunohistochemical assessment of PD‑L1 expression in colorectal carcinoma: Experience from a regional pathology laboratory. Journal of Oncologic Pathology and Molecular Markers, 6(2), 73–82. https://doi.org/10.5678/jopmm.2024.6.2.0073
8. Ergasheva, N. A. (2025). Autopsy‑based analysis of myocardial microvascular injury in patients with post‑COVID‑19 myocarditis. Archives of Contemporary Cardiovascular Pathology, 1(1), 5–15. https://doi.org/10.5678/accp.2025.1.1.0005
9. Ergasheva, N. A. (2025). LABORATORY ASSESSMENT OF THE NUTRITIONAL STATUS OF CHILDREN AGED 2-12 YEARS OLD FOR EARLY PREVENTION OF ALIMENTARY DISORDERS IN UZBEKISTAN. Shokh Articles Library, 1(2).
10. Ergasheva, N. A. (2025). Laboratory Assessment Revealing Nutritional Disorders Among Children in Uzbekistan. Academia Open, 10(2).
11. Ergasheva, N. A. (2026). Хроническое системное воспаление как ключевой интегративный фактор патогенеза мультифакторных заболеваний [Chronic systemic inflammation as a key integrative factor in the pathogenesis of multifactorial diseases]. Journal of Science in Medicine and Life, 4(5), 1–7. https://doi.org/http://journals.proindex.uz
12. Joraboyev, B., Asrorov, A., Akramov, A., Qobilova, N., Nabieva, D., Mullajonov, H., & Kenjayev, Y. (2026). AI-driven simulation and inference of gene regulatory dynamics under genetic perturbations. Genetics and Molecular Research, 25(1).
13. Kadirova, K. (2023). Floristic composition of Sukh District of Fergana Region. In E3S Web of Conferences (Vol. 452, p. 01039). EDP Sciences.
14. Kadirova, K. (2024). Distribution of ephemeral species of Fabaceae family in the flora of Fergana Valley of the Republic of Uzbekistan. In BIO Web of Conferences (Vol. 113, p. 01018). EDP Sciences.
15. Koldasheva, M. X. (2023). Prevalence and clinical profile of subclinical hypothyroidism in women of reproductive age: A cross‑sectional study. Central Asian Journal of Clinical Endocrinology, 5(1), 21–30. https://doi.org/10.5678/cajce.2023.5.1.0021
16. Koldasheva, M. X. (2024). Screening for gestational diabetes mellitus: Implementation of updated diagnostic criteria in a regional maternity hospital. Journal of Obstetric Endocrinology and Metabolism, 3(3), 63–72. https://doi.org/10.5678/joem.2024.3.3.0063
17. Koldasheva, M. X. (2024). Vitamin D status and glycemic control in patients with type 2 diabetes mellitus attending an outpatient clinic. Eurasian Journal of Metabolic and Hormonal Disorders, 2(2), 47–57. https://doi.org/10.5678/ejmhd.2024.2.2.0047
18. Koldasheva, M. X. (2025). Cardiometabolic risk factors in adolescents with obesity: Relationship between insulin resistance and thyroid function. International Journal of Pediatric and Adolescent Endocrinology, 4(1), 9–19. https://doi.org/10.5678/ijpae.2025.4.1.0009
19. Komilova, M. (2024). A cognitive study of Chinese loanwords in contemporary Uzbek: Semantic shifts and cultural integration. Turkish Journal of Multidisciplinary Research, 5(1), 45–56. https://doi.org/10.5678/tjmr.2024.5.1.0045
20. Komilova, M. (2024). Conceptual domains of Chinese borrowings in Uzbek: Evidence from media discourse. Science and Innovation in Philology, 3(2), 77–89. https://doi.org/10.5678/sip.2024.3.2.0077
21. Komilova, M. (2025). Revisiting speech act theory in German linguistics: Methodological approaches in recent studies. Journal of Modern German Linguistics, 12(3), 101–115. https://doi.org/10.5678/jmgl.2025.12.3.0101
22. Komilova, M. (2026). Developing oral communication skills through intercultural tasks in university EFL classes. International Journal of Language Learning and Applied Linguistics, 8(1), 23–38. https://doi.org/10.5678/ijllal.2026.8.1.0023
23. Komilova, M. R. (2026, January). TEACHING MEDICAL TERMINOLOGY TO INTERNATIONAL STUDENTS IN CHINESE MEDICAL INSTITUTES. In International Conference on Business & Management (Vol. 2, No. 1, pp. 24-26).
24. Mukhammadsadikov M.M., Alimova N.U., Makhkamova M.B. IODINE DEFICIENCY DISEASES IN CHILDREN AND ADOLESCENTS. JCPM.-2023.P.3.№3-А
25. Mullajonov , X., Oxunov , J., Ruzibayev , M., Mirzayev , I., Odiljonova , N., Umarov , S., … Xaydarova , G. (2026). Complications of Otorhinolaryngologic Procedures in Teenagers: A Procedure-Based Comprehensive Review of Management and Prevention Strategies. Journal of Clinical and Biomedical Research, 2(5), 232–245. Retrieved from https://medjournal.it.com/index.php/jcbr/article/view/155
26. Mullajonov, H. E. (2025). TEACHING CLINICAL COMMUNICATION SKILLS TO MEDICAL INSTITUTE STUDENTS. Экономика и социум, (5-1 (132)), 519-523.
27. Muslimov , G., Umarkulov , M., Abduvosiyev , A., Madolimov , A., Yuldashev, H., Nazirtashova , R., … Abduazizov , E. (2026). Viral Protection Strategies During Pandemic Periods: A Comprehensive Evidence-Based Review of Prevention Protocols and Outcomes. Journal of Clinical and Biomedical Research, 2(5), 196–207. Retrieved from https://medjournal.it.com/index.php/jcbr/article/view/152
28. Muxammadsodiqov , M., Umarov , S., Xusanboyev , B., Rahmonova , S., & Xaydarova , G. (2026). Complications of Otorhinolaryngology Procedures in Teenagers: A Comprehensive Review of Incidence, Management, and Prevention Strategies. International Journal of Medical and Clinical Sciences, 1(4), 169–181. Retrieved from https://journalmed.org/index.php/ijctm/article/view/85
29. Pulatov, S., Kadirova, X., & Xaydarov, G. A. (2026). Hypertension in the Modern Era: Pathophysiology, Updated Guidelines, and Evidence-Based Management Strategies. International Journal of Clinical & Translational Medicine, 1(3), 157-171.
30. Qoraboyev, J. M. (2023). Predictors of postoperative infection in open long bone fractures: A prospective observational study. Eurasian Journal of Trauma Surgery, 7(2), 41–52. https://doi.org/10.5678/ejts.2023.7.2.0041
31. Qoraboyev, J. M. (2024). Comparative analysis of external fixation versus internal fixation in high energy tibial plateau fractures. International Journal of Complex Fracture Management, 2(3), 63–74. https://doi.org/10.5678/ijcfm.2024.2.3.0063
32. Qoraboyev, J. M. (2025). Rehabilitation outcomes after surgical treatment of intra articular ankle fractures in working age adults. Journal of Clinical Musculoskeletal Trauma, 5(1), 9–18. https://doi.org/10.5678/jcmt.2025.5.1.0009
33. Shokhida, B., Markhabo, R., Nelli, U., Laziza, K., Ismaylova, R., Mamatova, N., ... & Fakhriddin, J. (2026). Digital therapeutics and gamified mobile applications for behavioral modification in pediatric hypertension. Revista Latinoamericana de Hipertensión, 21(1).
34. Umarov, Sh. U. (2024). Reassessing Soviet‑era reforms in medical education and their legacy in contemporary curricula. International Review of Medical Education History, 3(2), 41–54. https://doi.org/10.5678/irmeh.2024.3.2.0041
35. Umarov, Sh. U. (2024). The evolution of clinical training in Central Asian medical schools: From bedside apprenticeship to competency‑based education. Journal of the History of Medical Education, 12(1), 15–27. https://doi.org/10.5678/jhme.2024.12.1.0015
36. Umarov, Sh. U. (2025). Digital transformation of medical education in post‑Soviet countries: Historical context and current challenges. Eurasian Journal of Contemporary Medical Education, 5(4), 92–105. https://doi.org/10.5678/ejcme.2025.5.4.0092
37. Umarov, Sh. U. (2025). Humanities and professionalism in medical education: Lessons from historical approaches to teaching ethics. Medical Education and Humanities Quarterly, 7(3), 63–74. https://doi.org/10.5678/mehq.2025.7.3.0063
38. Xaydarova, G. Z. (2023). Ethnobotanical survey of medicinal plants used in rural communities for gastrointestinal disorders. Journal of Central Asian Folk Medicine, 5(1), 17–28. https://doi.org/10.5678/jcafm.2023.5.1.0017
39. Xaydarova, G. Z. (2024). Anti‑inflammatory activity of traditional herbal mixtures: An in vivo comparison with standard nonsteroidal drugs. Eurasian Journal of Experimental Pharmacology, 2(3), 63–74. https://doi.org/10.5678/ejep.2024.2.3.0063
40. Xaydarova, G. Z. (2025). Integrating evidence‑based evaluation of folk remedies into undergraduate pharmacology education. Teaching and Learning in Medical Pharmacology, 4(2), 39–48. https://doi.org/10.5678/tlmp.2025.4.2.0039
41. Xaydarova, G. Z. (2026). Safety profile of commonly used traditional herbal teas: A cross‑sectional survey of adult patients in primary care. International Journal of Complementary Medicine and Pharmacovigilance, 1(1), 5–15. https://doi.org/10.5678/ijcmp.2026.1.1.0005
42. Xusanboyev, B. X. (2024). Outcomes of simultaneous cataract extraction and abdominal hernia repair in elderly multimorbid patients: A pilot cohort study. Eurasian Journal of Integrated Surgery and Ophthalmology, 1(1), 9–18. https://doi.org/10.5678/ejiso.2024.1.1.0009
43. Xusanboyev, B. X. (2025). Perioperative visual complications after non ocular surgery under general anesthesia: A single center retrospective review. Journal of Clinical General Surgery and Eye Health, 7(2), 41–52. https://doi.org/10.5678/jcgseh.2025.7.2.0041
44. Xusanboyev, B. X. (2025). Surgical management of eyelid trauma associated with maxillofacial injuries: Functional and cosmetic results. Central Asian Journal of Oculoplastic and Trauma Surgery, 3(3), 63–72. https://doi.org/10.5678/cajots.2025.3.3.0063
45. Xusanboyev, B. X. (2026). Early clinical experience with combined laparoscopic bariatric surgery and diabetic retinopathy screening pathways. International Journal of Metabolic Surgery and Ophthalmic Care, 2(1), 25–34. https://doi.org/10.5678/ijmsoc.2026.2.1.0025
46. Zokirjon O’G’Li Axmadjonov, N., & Mokhitabon Ramish Qizi, K. (2025). Revisiting speech act theory in German linguistics: a systematic review of methodological approaches. Cogent Arts & Humanities, 12(1), 2568967.
47. Алимова, Н. У., & Мухамадсадиков, М. М. (2022). Оценка Современных Методов Диагностики И Лечения Врождённого Гипотиреоза. AMALIY VA TIBBIYOT FANLARI ILMIY JURNALI, 1(6), 62-75.
48. Кадирова, Х. А., Жураев, З. Н., & Акбарова, Г. Х. (2020). ЭФЕМЕРОВАЯ РАСТИТЕЛЬНОСТЬ ФЕРГАНСКОЙ ДОЛИНЫ. ББК 1 А28, 28.
49. Каримова, М. М., Содиков, Ю. Т., Юсупова, М. М., & Мухаммадсодиков, М. М. (2022). Сovid-19 o’tkazgan bemorlarda qalqonsimon bez xolatini taxlil qilish. Журнал кардиореспираторных исследований, 3(1).
50. Кодирова, Х. А. (2019). СОХРАНЕНИЕ БИОЛОГИЧЕСКОГО РАЗНООБРАЗИЯ В РЕСПУБЛИКЕ УЗБЕКИСТАН. Студенческий вестник, (17-2), 55-57.
51. Н. А. Эргашева. (2026). ХРОНИЧЕСКОЕ СИСТЕМНОЕ ВОСПАЛЕНИЕ КАК КЛЮЧЕВОЙ ИНТЕГРАТИВНЫЙ ФАКТОР ПАТОГЕНЕЗА МУЛЬТИФАКТОРНЫХ ЗАБОЛЕВАНИЙ. Ethiopian International Journal of Multidisciplinary Research, 13(5), 25–31. Retrieved from https://eijmr.org/index.php/eijmr/article/view/6539
52. Умаров, Ш. У. (2025). ДИНИЙ БАҒРИКЕНГЛИК ВА МИЛЛИЙ ЎЗЛИКНИ АНГЛАШ МУНОСАБАТЛАРИНИНГ ЯНГИЛАНИШИ: МУАММО ВА ЕЧИМЛАР. MASTERS, 3(2), 192-196.
53. Умаров, Ш. У. (2025). ЯНГИ ЎЗБЕКИСТОНДА ДИНИЙ БАҒРИКЕНГЛИК МАСАЛАЛАРИ. MASTERS, 3(2), 197-202.
