Improving Perinatal Care Strategies to Prevent Preterm Birth and Reduce Reproductive Losses
Keywords:
preterm birth, perinatal care, reproductive losses, antenatal corticosteroids, cervical screening, neonatal mortality, progesteroneAbstract
Background: Preterm birth remains a principal driver of neonatal morbidity and perinatal mortality in Central Asia. Objective: This study evaluated the effectiveness of a structured perinatal care intervention in reducing preterm birth rates and reproductive losses at the Perinatal Center of the Fergana Region compared with a matched cohort from Andijan. Methods: A prospective comparative study enrolled 112 patients in each group over 2022–2024. The intervention comprised antenatal corticosteroid prophylaxis, cervical length screening, progesterone supplementation, and multidisciplinary team-based care. Results: The Fergana cohort demonstrated a preterm birth rate of 6.4% versus 11.8% in Andijan (p < 0.001), with neonatal mortality reduced from 5.7% to 2.1% (p = 0.003). Overall perinatal losses declined by 59.5%. Conclusion: Comprehensive, protocol-driven perinatal care substantially reduces preterm birth incidence and reproductive losses in a regional setting.
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